イチキ　ヨシノブ   ICHIKI Yoshinobu   市来　嘉伸    所属   埼玉医科大学  医学部 国際医療センター　呼吸器外科    職種   専任講師
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Clinical significance of HLA class I alleles on postoperative prognosis of lung cancer patients in Japan.
掲載誌名	正式名：Lung cancer (Amsterdam, Netherlands)
巻・号・頁	65(1),91-7頁
著者・共著者	Yoshika Nagata,Takeshi Hanagiri,Makiko Mizukami,Koji Kuroda,Yoshiki Shigematsu,Tetsuro Baba,Yoshinobu Ichiki,Manabu Yasuda,Tomoko So,Mitsuhiro Takenoyama,Kenji Sugio,Akira Nagashima,Kosei Yasumoto
発行年月	2009/07
概要	BACKGROUND: The role of the HLA phenotype in cancer prognosis has been frequently discussed. We previously reported the correlation between HLA alleles and the postoperative prognosis of 204 patients with non-small cell lung cancer (NSCLC). The present study was based on 695 patients with NSCLC to confirm these correlations. METHODS: We evaluated the medical records of 695 NSCLC patients who underwent surgical resection. The serological typing of HLA class I was performed using a microcytotoxicity test of lymphocytes or PCR-sequence-specific oligonucleotides (PCR-SSO), and the correlation between the HLA alleles and the clinicopathological features was analyzed. The survival curves were calculated, and then a comparison of the survival curves was carried out. RESULTS: The HLA-A2 positive(A2(+)) group at stage I showed a more unfavorable prognosis than HLA-A2(-) group in overall survival. At stage II+III, the HLA-A24(+) group had a poorer prognosis than the HLA-A24(-) group, and the HLA-B52(+) group showed unfavorable prognosis. Multivariate analysis demonstrated that HLA-A2 at stage I and HLA-A24 at stage II+III were the independent factors that affected the survival period. CONCLU
DOI	10.1016/j.lungcan.2008.10.012
PMID	19054590