イチキ　ヨシノブ   ICHIKI Yoshinobu   市来　嘉伸    所属   埼玉医科大学  医学部 国際医療センター　呼吸器外科    職種   専任講師
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Discrimination of multiple primary lung cancers from intrapulmonary metastasis based on the expression of four cancer-related proteins.
掲載誌名	正式名：Cancer
巻・号・頁	115(15),3489-500頁
著者・共著者	Kenji Ono,Kenji Sugio,Hidetaka Uramoto,Tetsuro Baba,Yoshinobu Ichiki,Mitsuhiro Takenoyama,Takeshi Hanagiri,Tsunehiro Oyama,Kosei Yasumoto
発行年月	2009/08
概要	BACKGROUND: Because distinguishing between multiple primary lung cancers and intrapulmonary metastasis is often difficult when the tumor histology is same, the feasibility of analyzing differential protein expression profiles to distinguish multiple primary lung cancers from intrapulmonary metastasis was evaluated. METHODS: This study enrolled 50 patients, with multiple primary lung cancers demonstrating the same histology, who underwent surgery between April 1994 and March 2006 and 20 patients who were diagnosed to have intrapulmonary metastasis during the same period. Thirty patients with lymph-node metastasis were selected for comparison purposes. The sum value of the differences in the expression ratio of 4 proteins (p53, p16, p27, and c-erbB2) was evaluated in immunohistochemically stained specimens among multiple primary lung cancers and intrapulmonary metastasis. RESULTS: None of the 30 patients with lymph-node metastasis showed a sum value of the differences between primary tumor and lymph-node metastasis in the 4 protein expression ratios>90. Therefore, when the difference between 2 tumors exceeded 90, the 2 tumors were considered to be different from each other, ie, multi
DOI	10.1002/cncr.24382
PMID	19452548