イチキ　ヨシノブ   ICHIKI Yoshinobu   市来　嘉伸    所属   埼玉医科大学  医学部 国際医療センター　呼吸器外科    職種   専任講師
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Identification of a tumour associated antigen in lung cancer patients with asbestos exposure.
掲載誌名	正式名：Anticancer research
巻・号・頁	30(7),2631-9頁
著者・共著者	Manabu Yasuda,Takeshi Hanagiri,Yoshiki Shigematsu,Takamitsu Onitsuka,Kouji Kuroda,Tetsurou Baba,Makiko Mizukami,Yoshinobu Ichiki,Hidetaka Uramoto,Mitsuhiro Takenoyama,Kosei Yasumoto
発行年月	2010/07
概要	BACKGROUND: This study analysed the humoral immune response in asbestos exposed lung cancer patients to identify new surrogate markers of the carcinogenic risk in populations exposed to asbestos. METHODS AND RESULTS: A serological analysis identified five distinct antigens reactive with IgG derived from a lung cancer patient with high asbestos exposure. In one of the isolated antigens, quantitative RT-PCR indicated that annexin A2 (AnxA2) was overexpressed in lung cancer tissues and normal lung from patients with high asbestos exposure. Antibody against AnxA2 was detected in 9/15 (60%) of lung cancer patients with high asbestos exposure; however, in only 1/12 (8%) of lung cancer patients with low asbestos exposure. AnxA2 was also overexpressed in malignant mesothelioma cells, and the antibody was also positive in 8/15 (53%) of patients with malignant mesothelioma. CONCLUSION: The antibody titer against AnxA2 may be a potentially useful new diagnostic surrogate marker for asbestos-related lung cancer and malignant mesothelioma.
PMID	20682992