イチキ　ヨシノブ   ICHIKI Yoshinobu   市来　嘉伸    所属   埼玉医科大学  医学部 国際医療センター　呼吸器外科    職種   専任講師
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Detection of KK-LC-1 Protein, a Cancer/Testis Antigen, in Patients with Breast Cancer.
掲載誌名	正式名：Anticancer research
巻・号・頁	38(10),5923-5928頁
著者・共著者	Yasushi Kondo,Takashi Fukuyama,Rui Yamamura,Nobue Futawatari,Yoshinobu Ichiki,Yoichi Tanaka,Yatsushi Nishi,Yoshihito Takahashi,Hitoshi Yamazaki,Noritada Kobayashi,Masahiko Watanabe
発行年月	2018/10
概要	BACKGROUND: Kita-Kyushu lung cancer antigen-1 (KK-LC-1) is a cancer/testis antigen and predominant target for cancer immunotherapy. Its detection is only established based on gene expression. In this study, we established a monoclonal antibody against KK-LC-1 to detect its protein expression in formalin-fixed samples. MATERIALS AND METHODS: The monoclonal antibody against KK-LC-1 was evaluated and the detection of KK-LC-1 between gene expression and protein expression was compared in patients with breast cancer. The monoclonal antibody clone 34B3, which we established, stained testicular germ cells positively. RESULTS: The rates of detection of KK-LC-1 gene and protein expression were 11.8% and 52.9%, respectively. Protein expression was detected in all triple-negative breast cancer cases studied (n=8). Furthermore, KK-LC-1 was detected in all tumours without oestrogen receptor expression. CONCLUSION: This study indicated that KK-LC-1 expression was detected in breast cancer, especially in oestrogen receptor-negative subtypes.
DOI	10.21873/anticanres.12937
PMID	30275220