イチキ　ヨシノブ   ICHIKI Yoshinobu   市来　嘉伸    所属   埼玉医科大学  医学部 国際医療センター　呼吸器外科    職種   専任講師
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Predictive factors of postoperative survival among patients with pulmonary neuroendocrine tumor.
掲載誌名	正式名：Journal of thoracic disease
巻・号・頁	10(12),6912-6920頁
著者・共著者	Yoshinobu Ichiki,Hiroki Matsumiya,Masataka Mori,Masatoshi Kanayama,Yusuke Nabe,Akihiro Taira,Shinji Shinohara,Taiji Kuwata,Masaru Takenaka,Ayako Hirai,Naoko Imanishi,Kazue Yoneda,Hiroshi Noguchi,Shohei Shimajiri,Yoshihisa Fujino,Toshiyuki Nakayama,Fumihiro Tanaka
発行年月	2018/12
概要	Background: Pulmonary neuroendocrine tumor (NET) occurs with 20% of all lung cancers, and there are a limited number of literatures about the molecular aberrations, treatment and prognosis; especially in resected cases, as the operation indication for large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC) is rare due to their aggressive behaviors. We investigated the relationship between postoperative survival and molecular expression patterns of pulmonary NET to establish a more effective treatment strategy. Methods: In the present study, the curative surgical resection of pulmonary NET was reviewed retrospectively. A total of 105 patients with pulmonary NET, who underwent complete resection between 1978 and 2016, were subjected to analysis with respect to histological characterization and clinical behaviors of pulmonary NET using immunohistochemistry (IHC) of neuroendocrine markers and programmed cell death-ligand 1 (PD-L1). Results: The pathological types included 67 SCLC, 18 LCNEC, 14 typical carcinoids (TCs) and 6 atypical carcinoids (ACs). The ACs had significantly worse prognosis than TCs. PD-L1 expression ratio in SCLC/LCNEC/TC/AC was 26.1%/50%/15.
DOI	10.21037/jtd.2018.11.115
PMID	30746237