オノ　コウジ   ONO Koji   小野　公嗣    所属   埼玉医科大学  保健医療学部 臨床検査学科    職種   准教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice
掲載誌名	正式名：Neuropharmacology ISSNコード：18737064
出版社	Elsevier Ltd
巻・号・頁	72,58-65頁
著者・共著者	Kazuyoshi Kitaoka,Noriyuki Shimizu,Koji Ono,Sachiko Chikahisa,Madoka Nakagomi,Koichi Shudo,Kazunori Ishimura,Hiroyoshi Séi,Kazuo Yoshizaki
発行年月	2013
概要	The retinoic acid (RA, a vitamin A metabolite) receptor (RAR) is a transcription factor. Vitamin A/RA administration improves the Alzheimer's disease (AD)- and age-related attenuation ofmemory/learning in mouse models. Recently, a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)was identified as a key molecule in RA-mediated anti-AD mechanisms. We investigated the effect of chronic administration of the RAR agonist Am80 (tamibarotene) on ADAM10 expression in senescence-accelerated mice (SAMP8).Moreover, we estimated changes in the expression of the amyloid precursor protein (APP), amyloid beta (Aβ), and hairy/enhancer of split (Hes), which are mediated by ADAM10. Spatial working memory and the levels of a hippocampal proliferation marker (Ki67) were also assessed in these mice. ADAM10 mRNA and protein expression was significantly reduced in the hippocampus of 13-month-old SAMP8 mice their expression improved significantly after Am80 administration. Further, after Am80 administration, the expression levels of Hes5 and Ki67 were restored and the deterioration of working memory was suppressed, whereas APP and Aβ levels remained unchanged. Our results suggest
DOI	10.1016/j.neuropharm.2013.04.009