ジュウジョウ　ケンタロウ   JUJO Kentaro   重城　健太郎    所属   埼玉医科大学  医学部 総合医療センター　心臓内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	The Hedgehog Transcription Factor Gli3 Modulates Angiogenesis
掲載誌名	正式名：CIRCULATION RESEARCH ISSNコード：00097330
出版社	LIPPINCOTT WILLIAMS&WILKINS
巻・号・頁	105(8),818-U252頁
著者・共著者	Marie-Ange Renault,Jerome Roncalli,Joern Tongers,Sol Misener,Tina Thorne,Kentaro Jujo,Aiko Ito,Trevor Clarke,Chris Fung,Meredith Millay,Christine Kamide,Andrew Scarpelli,Ekaterina Klyachko,Douglas W. Losordo
発行年月	2009/10
概要	Rationale: The Gli transcription factors are mediators of Hedgehog (Hh) signaling and have been shown to play critical roles during embryogenesis. Previously, we have demonstrated that the Hh pathway is reactivated by ischemia in adult mammals, and that this pathway can be stimulated for therapeutic benefit; however, the specific roles of the Gli transcription factors during ischemia-induced Hh signaling have not been elucidated.Objective: To investigate the role of Gli3 in ischemic tissue repair.Methods and Results: Gli3-haploinsufficient (Gli3(+/-)) mice and their wild-type littermates were physiologically similar in the absence of ischemia; however, histological assessments of capillary density and echocardiographic measurements of left ventricular ejection fractions were reduced in Gli3(+/-) mice compared to wild-type mice after surgically induced myocardial infarction, and fibrosis was increased. Gli3-deficient mice also displayed reduced capillary density after induction of hindlimb ischemia and an impaired angiogenic response to vascular endothelial growth factor in the corneal angiogenesis model. In endothelial cells, adenovirus-mediated overexpression of Gli3 promoted mi
DOI	10.1161/CIRCRESAHA.109.206706