ジュウジョウ　ケンタロウ   JUJO Kentaro   重城　健太郎    所属   埼玉医科大学  医学部 総合医療センター　心臓内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	CXCR4 Antagonist AMD3100 Accelerates ImpairedWound Healing in Diabetic Mice
掲載誌名	正式名：JOURNAL OF INVESTIGATIVE DERMATOLOGY ISSNコード：0022202X
出版社	NATURE PUBLISHING GROUP
巻・号・頁	132(3),711-720頁
著者・共著者	Yukihide Nishimura,Masaaki Ii,Gangjian Qin,Hiromichi Hamada,Jun Asai,Hideya Takenaka,Haruki Sekiguchi,Marie-Ange Renault,Kentaro Jujo,Norito Katoh,Saburo Kishimoto,Aiko Ito,Christine Kamide,John Kenny,Meredith Millay,Sol Misener,Tina Thorne,Douglas W. Losordo
発行年月	2012/03
概要	The antagonism of CXC-chemokine receptor 4 (CXCR4) with AMD3100 improves cardiac performance after myocardial infarction by augmenting the recruitment of endothelial progenitor cells (EPCs) from the bone marrow to the regenerating vasculature. We investigated whether AMD3100 may accelerate diabetes-impaired wound healing through a similar mechanism. Skin wounds were made on the backs of leptin receptor-deficient mice and treated with AMD3100 or saline. Fourteen days after treatment, wound closure was significantly more complete in AMD3100-treated mice (AMD3100: 87.0 +/- 2.6%, saline: 33.1 +/- 1.8%; P<0.0001) and was accompanied by greater collagen fiber formation, capillary density, smooth muscle-containing vessel density, and monocyte/macrophage infiltration. On day 7 after treatment, AMD3100 was associated with higher circulating EPC and macrophage counts, and with significantly upregulated mRNA levels of stromal cell-derived factor 1 and platelet-derived growth factor B in the wound bed. AMD3100 also promoted macrophage proliferation and phagocytosis and the migration and proliferation of diabetic mouse primary dermal fibroblasts and 3T3 fibroblasts, which express very little
DOI	10.1038/jid.2011.356