ジュウジョウ　ケンタロウ   JUJO Kentaro   重城　健太郎    所属   埼玉医科大学  医学部 総合医療センター　心臓内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	The impact of tissue Doppler index E/e′ ratio on instantaneous wave-free ratio
掲載誌名	正式名：Journal of Cardiology ISSNコード：18764738
出版社	Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai)
巻・号・頁	71(3),237-243頁
著者・共著者	Hiroyuki Arashi,Junichi Yamaguchi,Tonre Ri,Hisao Otsuki,Masashi Nakao,Kazuho Kamishima,Kentaro Jujo,Yuichiro Minami,Hiroshi Ogawa,Nobuhisa Hagiwara
発行年月	2018/03
概要	Background: The instantaneous wave-free ratio (iFR) is a vasodilator-free, invasive pressure wire index of the functional severity of coronary stenosis and is calculated under resting conditions. In a recent study, iFR was found to be more closely linked to coronary flow reserve (CFR) than fractional flow reserve (FFR). E/e′ is a surrogate marker of left ventricular (LV) filling pressure and LV diastolic dysfunction. Coronary resting flow was found to be increased in patients with elevated E/e′, and higher coronary resting flow was associated with lower CFR. Higher baseline coronary flow induces a greater loss of translesional pressure and may affect iFR. However, no reports have examined the impact of E/e′ on iFR. The purpose of this study was to assess the relationship between iFR and E/e′ compared with FFR. Methods and results: We retrospectively examined 103 consecutive patients (142 with stenosis) whose iFR, FFR, and E/e′ were measured simultaneously. The mean age, LV mass index, and systolic blood pressure of patients with elevated E/e′ were higher than those of patients with normal E/e′. Although no significant differences were observed in mean FFR values and %
DOI	10.1016/j.jjcc.2017.09.003