ジュウジョウ　ケンタロウ   JUJO Kentaro   重城　健太郎    所属   埼玉医科大学  医学部 総合医療センター　心臓内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Aspartate aminotransferase to alanine aminotransferase ratio is associated with frailty and mortality in older patients with heart failure.
掲載誌名	正式名：Scientific reports
巻・号・頁	11(1),11957-11957頁
著者・共著者	DaichiMaeda,Nobuyuki Kagiyama,Kentaro Jujo,Kazuya Saito,Kentaro Kamiya,Hiroshi Saito,Yuki Ogasahara,Emi Maekawa,Masaaki Konishi,Takeshi Kitai,Kentaro Iwata,Hiroshi Wada,Masaru Hiki,Taishi Dotare,Tsutomu Sunayama,Takatoshi Kasai,Hirofumi Nagamatsu,Tetsuya Ozawa,Katsuya Izawa,Shuhei Yamamoto,Naoki Aizawa,Ryusuke Yonezawa,Kazuhiro Oka,Shin-Ichi Momomura,Yuya Matsue
発行年月	2021/06
概要	Frailty is a common comorbidity associated with adverse events in patients with heart failure, and early recognition is key to improving its management. We hypothesized that the AST to ALT ratio (AAR) could be a marker of frailty in patients with heart failure. Data from the FRAGILE-HF study were analyzed. A total of 1327 patients aged ≥ 65 years hospitalized with heart failure were categorized into three groups based on their AAR at discharge: low AAR (AAR < 1.16, n = 434); middle AAR (1.16 ≤ AAR < 1.70, n = 487); high AAR (AAR ≥ 1.70, n = 406). The primary endpoint was one-year mortality. The association between AAR and physical function was also assessed. High AAR was associated with lower short physical performance battery and shorter 6-min walk distance, and these associations were independent of age and sex. Logistic regression analysis revealed that high AAR was an independent marker of physical frailty after adjustment for age, sex and body mass index. During follow-up, all-cause death occurred in 161 patients. After adjusting for confounding factors, high AAR was associated with all-cause death (low AAR vs. high AAR, hazard ratio: 1.
DOI	10.1038/s41598-021-91368-z
PMID	34099767