ジュウジョウ　ケンタロウ   JUJO Kentaro   重城　健太郎    所属   埼玉医科大学  医学部 総合医療センター　心臓内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Standardized gait speed ratio in elderly patients with heart failure.
掲載誌名	正式名：ESC heart failure
著者・共著者	Tetsuya Ozawa,Masashi Yamashita,Satoshi Seino,Kentaro Kamiya,Nobuyuki Kagiyama,Masaaki Konishi,Hiroshi Saito,Kazuya Saito,Yuki Ogasahara,Emi Maekawa,Takeshi Kitai,Kentaro Iwata,Kentaro Jujo,Hiroshi Wada,Takatoshi Kasai,Shin-Ichi Momomura,Nobuaki Hamazaki,Kohei Nozaki,Hunkyung Kim,Shuichi Obuchi,Hisashi Kawai,Akihiko Kitamura,Shoji Shinkai,Yuya Matsue
発行年月	2021/07
概要	AIMS: Although aging is strongly associated with both heart failure and a decline in gait speed, a definition of slowness incorporating an age-related decline has yet to be developed. We aimed to define an event-driven cut-off for the relative decline in gait speed against age-adjusted reference values derived from the general population and evaluate its prognostic implications. METHODS AND RESULTS: Standardized gait speed (SGS) was defined as the median gait speed stratified by age, sex, and height in 3777 elderly (age ≥ 65 years) individuals without a history of cardiovascular diseases (Tokyo Metropolitan Institute of Gerontology-Longitudinal Interdisciplinary Study on Aging: general population cohort). The mortality event-driven optimal cut-off of the SGS ratio (actual gait speed divided by the respective SGS) was defined using FRAGILE-HF cohort data and externally validated using Kitasato cohort data, comprising 1301 and 1247 hospitalized elderly patients with heart failure, respectively. Using FRAGILE-HF data, the optimal SGS ratio cut-off was determined as 0.527. In the Kitasato cohort, SGS ratio < 0.527 was associated with a higher 1 year [hazard ratio (HR): 1.70, 95
DOI	10.1002/ehf2.13392
PMID	34245132