スオウ　サトシ   SUOU SATOSHI   周防　諭    所属   埼玉医科大学  医学部 薬理学    職種   准教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Aβ induces oxidative stress in senescence-accelerated (SAMP8) mice.
掲載誌名	正式名：Bioscience, Biotechnology, and Biochemistry
出版社	Taylar and Francis
巻・号・頁	79(6),912-918頁
著者・共著者	Kurara Takagane, Jun Nojimb, Hiroaki Mitsuhashi, Satoshi Suo, Dai Yanagihara, Fumio Takaiwa, Yasuomi Urano, Noriko Noguchi & Shoichi Ishiura
発行年月	2015/06
概要	According to the amyloid hypothesis, amyloid β accumulates in brains with Alzheimer's disease (AD) and triggers cell death and memory deficit. Previously, we developed a rice Aβ vaccine expressing Aβ, which reduced brain Aβ levels in the Tg2576 mouse model of familial AD. We used senescence-accelerated SAMP8 mice as a model of sporadic AD and investigated the relationship between Aβ and oxidative stress. Insoluble Aβ and 4-hydroxynonenal (4-HNE) levels tended to be reduced in SAMP8 mice-fed the rice Aβ vaccine. We attempted to clarify the relationship between oxidative stress and Aβ in vitro. Addition of Aβ peptide to the culture medium resulted in an increase in 4-HNE levels in SH-SY5Y cells. Tg2576 mice, which express large amounts of Aβ in their brain, also exhibited increased 4-HNE levels; this increase was inhibited by the Aβ vaccine. These results indicate that Aβ induces oxidative stress in cultured cells and in the mouse brain.