シノジマ　トシアキ   SHINOJIMA Toshiaki   篠島　利明    所属   埼玉医科大学  医学部 泌尿器科    職種   准教授
論文種別	学術雑誌(症例報告)
言語種別	英語
査読の有無	査読あり
表題	Dexamethasone and interleukin-2 combination therapy for advanced renal cell carcinoma in a patient with paraneoplastic inflammatory syndrome.
掲載誌名	正式名：International journal of urology : official journal of the Japanese Urological Association 略　 称：Int J Urol
掲載区分	国外
巻・号・頁	11(7),553-6頁
著者・共著者	Shinojima Toshiaki, Oya Mototsugu, Kohno Hidaka, Marumo Ken, Murai Masaru
発行年月	2004/07
概要	Interleukin-2 (IL-2) in combination with dexamethasone was administered to a 48-year-old man with renal cell carcinoma accompanied by paraneoplastic inflammatory syndrome, including progressive multiple lung metastases and inferior vena caval tumor thrombus. Although non-steroidal anti-inflammatory drugs had no apparent antipyretic effect on the systemic inflammatory syndrome, oral administration of dexamethasone achieved complete antipyresis and improved his quality of life. After a 4-week period of IL-2 treatment, regression of metastasized lesions was demonstrated despite concurrent oral administration of dexamethasone. Steroids might reduce the action of immunotherapeutic drugs, but in some cases, combination therapy can achieve both alleviation of the paraneoplastic syndrome and tumor shrinkage.
DOI	10.1111/j.1442-2042.2004.00831.x
PMID	15242368