セキ　マサフミ   SEK Masafumi   関　雅文    所属   埼玉医科大学  医学部 国際医療センター　感染症科・感染制御科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Gabexate mesilate suppresses influenza pneumonia in mice through inhibition of cytokines
掲載誌名	正式名：JOURNAL OF INTERNATIONAL MEDICAL RESEARCH ISSNコード：03000605
出版社	FIELD HOUSE PUBLISHING LLP
巻・号・頁	36(2),322-328頁
著者・共著者	K. Kosai,M. Seki,K. Yanagihara,S. Nakamura,S. Kurihara,K. Izumikawa,H. Kakeya,Y. Yamamoto,T. Tashiro,S. Kohno
発行年月	2008/03
概要	Gabexate mesilate is a synthetic protease inhibitor that is effective for acute pancreatitis. The effect of gabexate mesilate in influenza pneumonia in mice was investigated by examining the changes in pulmonary inflammatory cytokines and chemokines. Pathological changes in the lungs of treated mice were extremely mild, compared with changes in infected, untreated mice. Intrapulmonary levels of interleukin-6 and macrophage inflammatory protein-2 decreased in treated mice compared with untreated mice, despite similar viral titres in the lungs. Survival terms for treated and untreated groups were similar. These data indicate that gabexate mesilate has beneficial effects on influenza pneumonia, which may be due to the modulation of inflammatory cytokine/chemokine responses.