セキ　マサフミ   SEK Masafumi   関　雅文    所属   埼玉医科大学  医学部 国際医療センター　感染症科・感染制御科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Evaluation of a rapid immunochromatographic ODK0501 assay for detecting Streptococcus pneumoniae antigen in sputum samples from patients with lower respiratory tract infection.
掲載誌名	正式名：Clinical and vaccine immunology : CVI ISSNコード：15566811
巻・号・頁	16(5),672-8頁
著者・共著者	Koichi Izumikawa,Suguru Akamatsu,Akiko Kageyama,Kiyomi Okada,Yukumasa Kazuyama,Noboru Takayanagi,Shigeki Nakamura,Yuichi Inoue,Yasuhito Higashiyama,Kiyoyasu Fukushima,Tadashi Ishida,Toyomitsu Sawai,Kunihiko Yoshimura,Chikara Nakahama,Mitsuhide Ohmichi,Tomoyuki Kakugawa,Yasuhiko Nishioka,Nobuki Aoki,Masafumi Seki,Hiroshi Kakeya,Yoshihiro Yamamoto,Katsunori Yanagihara,Shigeru Kohno
発行年月	2009/05
概要	A novel, rapid, and noninvasive test (ODK0501) to detect Streptococcus pneumoniae antigen was evaluated in a Japanese multicenter study. ODK0501 uses polyclonal antibodies to detect C polysaccharide of S. pneumoniae from sputum samples by an immunochromatographic assay. The utility of ODK0501 was evaluated for 161 adult patients with lower respiratory tract infection between March 2006 and March 2007. Bacterial culture and identification, real-time PCR, and ODK0501 assays were performed on sputum samples, and the Binax Now Streptococcus pneumoniae antigen test was performed using urine samples obtained from the same patients. The performances of all tests were compared based on the results of bacterial culture and identification. The sensitivity and specificity of ODK0501 were 89.1% (49/55 samples) and 95.3% (101/106 samples), respectively. We then compared the Binax Now Streptococcus pneumoniae antigen test with ODK0501 using samples from 142 patients. The sensitivities of ODK0501 and the Binax Now S. pneumoniae antigen test were 90.0% (45/50 samples) and 62.0% (31/50 samples), respectively (P = 0.002). The relative quantity of S. pneumoniae in expectorated sputum was calculated u
DOI	10.1128/CVI.00308-08
PMID	19261775