イタザワ トシコ
ITAZAWA TOSHIKO
板澤 寿子 所属 埼玉医科大学 医学部 小児科(小児科、新生児科) 職種 教授 |
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論文種別 | 学術雑誌(原著) |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Excision release of 5?hydroxycytosine oxidatively induced DNA base lesions from the lung genome by cat dander extract challenge stimulates allergic airway inflammation. |
掲載誌名 | 正式名:Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology |
巻・号・頁 | 48(12),1676-1687頁 |
著者・共著者 | Koa Hosoki,Pawel Jaruga,Toshiko Itazawa,Leopoldo Aguilera-Aguirre,Erdem Coskun,Tapas K Hazra,Istvan Boldogh,Miral Dizdaroglu,Sanjiv Sur |
発行年月 | 2018/12 |
概要 | BACKGROUND: Ragweed pollen extract (RWPE) induces TLR4-NFκB-CXCL-dependent recruitment of ROS-generating neutrophils to the airway and OGG1 DNA glycosylase-dependent excision of oxidatively induced 8-OH-Gua DNA base lesions from the airway epithelial cell genome. Administration of free 8-OH-Gua base stimulates RWPE-induced allergic lung inflammation. These studies suggest that stimulation of innate receptors and their adaptor by allergenic extracts initiates excision of a set of DNA base lesions that facilitate innate/allergic lung inflammation. OBJECTIVE: To test the hypothesis that stimulation of a conserved innate receptor/adaptor pathway by allergenic extracts induces excision of a set of pro-inflammatory oxidatively induced DNA base lesions from the lung genome that stimulate allergic airway inflammation. |
DOI | 10.1111/cea.13284 |
PMID | 30244512 |