クワバラ　ヒトシ   KUWABARA Hitoshi   桑原　斉    所属   埼玉医科大学  医学部 神経精神科・心療内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Parental age and assisted reproductive technology in autism spectrum disorders, attention deficit hyperactivity disorder, and Tourette syndrome in a Japanese population
掲載誌名	正式名：RESEARCH IN AUTISM SPECTRUM DISORDERS ISSNコード：17509467
出版社	ELSEVIER SCI LTD
巻・号・頁	6(1),500-507頁
著者・共著者	Takafumi Shimada,Atsushi Kitamoto,Ayako Todokoro,Ayaka Ishii-Takahashi,Hitoshi Kuwabara,Soo-Yung Kim,Kei-ichiro Watanabe,Iwao Minowa,Toshikazu Someya,Hiroshi Ohtsu,Yutaka Osuga,Yukiko Kano,Kiyoto Kasai,Nobumasa Kato,Tsukasa Sasaki
発行年月	2012/01
概要	We investigated whether advanced parental age and assisted reproductive technology (ART) are risk factors in autism spectrum disorders (ASDs), attention deficit hyperactivity disorder (ADHD), and burette syndrome (TS). Clinical charts of Japanese outpatients with ASD (n = 552), ADHD = 87), and TS = 123) were reviewed. Parental age of individuals with ASD, ADHD, or TS was compared with parental age in the general population (GP) of Tokyo after adjusting for year of birth. Paternal and maternal ages were significantly higher in persons with ASD and ADHD, but not those with TS. In final steps of stepwise logistic regression analysis, both maternal and paternal age were associated with ASD after controlling for the other parent's age, gender, and birth order. In cases where the presence or absence of ART could be ascertained (ASD n = 467: ADHD n = 64; TS n = 83), the rate of ART in cases of persons with ASD (4.5%) was 1.8 times the frequency expected in the GP, while ART was not present in cases of persons with ADHD and TS. These preliminary results remain tentative pending replication with larger, community-based samples. (C) 2011 Elsevier Ltd. All rights reserved.
DOI	10.1016/j.rasd.2011.07.010