クワバラ　ヒトシ   KUWABARA Hitoshi   桑原　斉    所属   埼玉医科大学  医学部 神経精神科・心療内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Electrophysiological abnormalities of spatial attention in adults with autism during the gap overlap task
掲載誌名	正式名：CLINICAL NEUROPHYSIOLOGY ISSNコード：13882457
出版社	ELSEVIER IRELAND LTD
巻・号・頁	118(7),1464-1471頁
著者・共著者	Yuki Kawakubo,Kiyoto Kasai,Shinji Okazaki,Miyuki Hosokawa-Kakurai,Kei-ichiro Watanabe,Hitoshi Kuwabara,Michiko Ishijima,Hidenori Yamasue,Akira Iwanami,Nobumasa Kato,Hisao Maekawa
発行年月	2007/07
概要	Objective: We evaluated event-related potentials (ERPs) elicited by attentional disengagement in individuals with autism.Methods: Sixteen adults with autism, 17 adults with mental retardation and 14 healthy adults participated in this study. We recorded the pre-saccade positive ERPs during the gap overlap task under which a peripheral stimulus was presented subsequent to a stimulus in the central visual field. Under the overlap condition, the central stimulus remained during the presentation of the peripheral stimulus and therefore participants need to disengage their attention intentionally in order to execute the saccade to the peripheral stimulus due to the preservation of the central stimulus.Results: The autism group elicited significantly higher pre-saccadic positivity during a period of 100-70 ms prior to the saccade onset than the other groups only underthe overlap condition. The higher amplitude of pre-saccadic positivity in the overlap condition was significantly correlated with more severe clinical symptoms within the autism group.Conclusions: These results demonstrate electrophysiological abnormalities of disengagement during visuospatial attention in adults with aut
DOI	10.1016/j.clinph.2007.04.015
PMID	17532260