クワバラ　ヒトシ   KUWABARA Hitoshi   桑原　斉    所属   埼玉医科大学  医学部 神経精神科・心療内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Impaired Prefrontal Hemodynamic Maturation in Autism and Unaffected Siblings
掲載誌名	正式名：PLOS ONE ISSNコード：19326203
出版社	PUBLIC LIBRARY SCIENCE
巻・号・頁	4(9),e6881頁
著者・共著者	Yuki Kawakubo,Hitoshi Kuwabara,Kei-ichiro Watanabe,Michiko Minowa,Toshikazu Someya,Iwao Minowa,Toshiaki Kono,Hisami Nishida,Toshiro Sugiyama,Nobumasa Kato,Kiyoto Kasai
発行年月	2009/09
概要	Background: Dysfunctions of the prefrontal cortex have been previously reported in individuals with autism spectrum disorders (ASD). Previous studies reported that first-degree relatives of individuals with ASD show atypical brain activity during tasks associated with social function. However, developmental changes in prefrontal dysfunction in ASD and genetic influences on the phenomena remain unclear. In the present study, we investigated the change in hemoglobin concentration in the prefrontal cortex as measured with near-infrared spectroscopy, in children and adults with ASD during the letter fluency test. Moreover, to clarify the genetic influences on developmental changes in the prefrontal dysfunction in ASD, unaffected siblings of the ASD participants were also assessed.Methodology/Principal Findings: Study participants included 27 individuals with high-functioning ASD, age-and IQ-matched 24 healthy non-affected siblings, and 27 unrelated healthy controls aged 5 to 39 years. The relative concentration of hemoglobin ([Hb]) in the prefrontal cortex was measured during the letter fluency task. For children, neither the [oxy-Hb]change during the task nor task performances diffe
DOI	10.1371/journal.pone.0006881
PMID	19727389