クワバラ　ヒトシ   KUWABARA Hitoshi   桑原　斉    所属   埼玉医科大学  医学部 神経精神科・心療内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Reduced Gray Matter Volume of Pars Opercularis Is Associated with Impaired Social Communication in High-Functioning Autism Spectrum Disorders
掲載誌名	正式名：BIOLOGICAL PSYCHIATRY ISSNコード：00063223
出版社	ELSEVIER SCIENCE INC
巻・号・頁	68(12),1141-1147頁
著者・共著者	Syudo Yamasaki,Hidenori Yamasue,Osamu Abe,Motomu Suga,Haruyasu Yamada,Hideyuki Inoue,Hitoshi Kuwabara,Yuki Kawakubo,Noriaki Yahata,Shigeki Aoki,Yukiko Kano,Nobumasa Kato,Kiyoto Kasai
発行年月	2010/12
概要	Background: Recent literature suggests that the inferior frontal gyrus, especially its posterior portion, has an important role inimitation and social reciprocity and in the pathophysiology of their disturbance in autism spectrum disorders (ASD). However, the structural abnormality of this region has not fully been clarified in subjects with ASD.Methods: Here we obtained magnetic resonance images from 13 right-handed men with high-functioning ASD(Asperger disorder [n = 10]or autism [n = 3]) and from 11 age-, parental socioeconomic background-, and intelligence quotient-matched right-handed typical men. A reliable manual tracing methodology was employed to measure the gray matter volume of the pars opercularis, corresponding to Brodmann area 44, and the pars triangularis, corresponding to Brodmann area 45.Results: A significant gray matter volume reduction of both the pars opercularis and triangularis was found bilaterally in the subjects with ASD compared with the typical control subjects. The effect size seemed to be larger for pars opercularis (1.25) than for pars triangularis (.90). The reduced volume of right as well as total pars opercularis showed a significant associatio
DOI	10.1016/j.biopsych.2010.07.012
PMID	20801427