クワバラ　ヒトシ   KUWABARA Hitoshi   桑原　斉    所属   埼玉医科大学  医学部 神経精神科・心療内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Developmental Changes of Prefrontal Activation in Humans: A Near-Infrared Spectroscopy Study of Preschool Children and Adults
掲載誌名	正式名：PLOS ONE ISSNコード：19326203
出版社	PUBLIC LIBRARY SCIENCE
巻・号・頁	6(10),e25944頁
著者・共著者	Yuki Kawakubo,Toshiaki Kono,Ryu Takizawa,Hitoshi Kuwabara,Ayaka Ishii-Takahashi,Kiyoto Kasai
発行年月	2011/10
概要	Previous morphological studies indicated that development of the human prefrontal cortex (PFC) appears to continue into late adolescence. Although functional brain imaging studies have sought to determine the time course of functional development of the PFC, it is unclear whether the developmental change occurs after adolescence to adulthood and when it achieves a peak because of the narrow or discontinuous range in the participant's age. Moreover, previous functional studies have not focused on the anterior frontal region, that is, the frontopolar regions (BA9/10). Thus, the present study investigated the developmental change in frontopolar PFC activation associated with letter fluency task by using near-infrared spectroscopy (NIRS), in subjects from preschool children to adults. We analyzed the relative concentration of hemoglobin (Delta Hb) in the prefrontal cortex measured during the activation task in 48 typically-developing children and adolescents and 22 healthy adults. Consistent with prior morphological studies, we found developmental change with age in the children/adolescents. Moreover, the average Delta oxy-Hb in adult males was significantly larger than that in child/a
DOI	10.1371/journal.pone.0025944
PMID	22022479