クワバラ　ヒトシ   KUWABARA Hitoshi   桑原　斉    所属   埼玉医科大学  医学部 神経精神科・心療内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Diminished Medial Prefrontal Activity behind Autistic Social Judgments of Incongruent Information
掲載誌名	正式名：PLOS ONE ISSNコード：19326203
出版社	PUBLIC LIBRARY SCIENCE
巻・号・頁	7(6),e39561頁
著者・共著者	Takamitsu Watanabe,Noriaki Yahata,Osamu Abe,Hitoshi Kuwabara,Hideyuki Inoue,Yosuke Takano,Norichika Iwashiro,Tatsunobu Natsubori,Yuta Aoki,Hidemasa Takao,Hiroki Sasaki,Wataru Gonoi,Mizuho Murakami,Masaki Katsura,Akira Kunimatsu,Yuki Kawakubo,Hideo Matsuzaki,Kenji J. Tsuchiya,Nobumasa Kato,Yukiko Kano,Yasushi Miyashita,Kiyoto Kasai,Hidenori Yamasue
発行年月	2012/06
概要	Individuals with autism spectrum disorders (ASD) tend to make inadequate social judgments, particularly when the nonverbal and verbal emotional expressions of other people are incongruent. Although previous behavioral studies have suggested that ASD individuals have difficulty in using nonverbal cues when presented with incongruent verbal-nonverbal information, the neural mechanisms underlying this symptom of ASD remain unclear. In the present functional magnetic resonance imaging study, we compared brain activity in 15 non-medicated adult males with high-functioning ASD to that of 17 age-, parental-background-, socioeconomic-, and intelligence-quotient-matched typically-developed (TD) male participants. Brain activity was measured while each participant made friend or foe judgments of realistic movies in which professional actors spoke with conflicting nonverbal facial expressions and voice prosody. We found that the ASD group made significantly less judgments primarily based on the nonverbal information than the TD group, and they exhibited significantly less brain activity in the right inferior frontal gyrus, bilateral anterior insula, anterior cingulate cortex/ventral medial pr
DOI	10.1371/journal.pone.0039561
PMID	22745788