クワバラ　ヒトシ   KUWABARA Hitoshi   桑原　斉    所属   埼玉医科大学  医学部 神経精神科・心療内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Prefrontal activation during inhibitory control measured by near-infrared spectroscopy for differentiating between autism spectrum disorders and attention deficit hyperactivity disorder in adults
掲載誌名	正式名：NEUROIMAGE-CLINICAL ISSNコード：22131582
出版社	ELSEVIER SCI LTD
巻・号・頁	4,53-63頁
著者・共著者	Ayaka Ishii-Takahashi,Ryu Takizawa,Yukika Nishimura,Yuki Kawakubo,Hitoshi Kuwabara,Junko Matsubayashi,Kasumi Hamada,Shiho Okuhata,Noriaki Yahata,Takashi Igarashi,Shingo Kawasaki,Hidenori Yamasue,Nobumasa Kato,Kiyoto Kasai,Yukiko Kano
発行年月	2014
概要	The differential diagnosis of autism spectrum disorders (ASDs) and attention deficit hyperactivity disorder (ADHD) based solely on symptomatic and behavioral assessments can be difficult, even for experts. Thus, the development of a neuroimaging marker that differentiates ASDs from ADHD would be an important contribution to this field. We assessed the differences in prefrontal activation between adults with ASDs and ADHD using an entirely non-invasive and portable neuroimaging tool, near-infrared spectroscopy. This study included 21 drug naive adults with ASDs, 19 drug-naive adults with ADHD, and 21 healthy subjects matched for age, sex, and IQ. Oxygenated hemoglobin concentration changes in the prefrontal cortex were assessed during a stop signal task and a verbal fluency task. During the stop signal task, compared to thecontrol group, the ASDs group exhibited lower activation in a broad prefrontal area, whereas the ADHD group showed underactivation of the right premotor area, right presupplementary motor area, and bilateral dorsolateral prefrontal cortices. Significant differences were observed in the left ventrolateral prefrontal cortex between the ASDs and ADHD groups during t
DOI	10.1016/j.nicl.2013.10.002
PMID	24298446