クワバラ　ヒトシ   KUWABARA Hitoshi   桑原　斉    所属   埼玉医科大学  医学部 神経精神科・心療内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Oxytocin improves behavioural and neural deficits in inferring others' social emotions in autism
掲載誌名	正式名：BRAIN ISSNコード：00068950
出版社	OXFORD UNIV PRESS
巻・号・頁	137(Pt 11),3073-3086頁
著者・共著者	Yuta Aoki,Noriaki Yahata,Takamitsu Watanabe,Yosuke Takano,Yuki Kawakubo,Hitoshi Kuwabara,Norichika Iwashiro,Tatsunobu Natsubori,Hideyuki Inoue,Motomu Suga,Hidemasa Takao,Hiroki Sasaki,Wataru Gonoi,Akira Kunimatsu,Kiyoto Kasai,Hidenori Yamasue
発行年月	2014/11
概要	Recent studies have suggested oxytocin's therapeutic effects on deficits in social communication and interaction in autism spectrum disorder through improvement of emotion recognition with direct emotional cues, such as facial expression and voice prosody. Although difficulty in understanding of others' social emotions and beliefs under conditions without direct emotional cues also plays an important role in autism spectrum disorder, no study has examined the potential effect of oxytocin on this difficulty. Here, we sequentially conducted both a case-control study and a clinical trial to investigate the potential effects of oxytocin on this difficulty at behavioural and neural levels measured using functional magnetic resonance imaging during a psychological task. This task was modified from the Sally-Anne Task, a well-known first-order false belief task. The task was optimized for investigation of the abilities to infer another person's social emotions and beliefs distinctively so as to test the hypothesis that oxytocin improves deficit in inferring others' social emotions rather than beliefs, under conditions without direct emotional cues. In the case-control study, 17 males with
DOI	10.1093/brain/awu231
PMID	25149412