クワバラ　ヒトシ   KUWABARA Hitoshi   桑原　斉    所属   埼玉医科大学  医学部 神経精神科・心療内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Neuroimaging-Aided Prediction of the Effect of Methylphenidate in Children with Attention-Deficit Hyperactivity Disorder: A Randomized Controlled Trial
掲載誌名	正式名：NEUROPSYCHOPHARMACOLOGY ISSNコード：0893133X
出版社	NATURE PUBLISHING GROUP
巻・号・頁	40(12),2676-2685頁
著者・共著者	Ayaka Ishii-Takahashi,Ryu Takizawa,Yukika Nishimura,Yuki Kawakubo,Kasumi Hamada,Shiho Okuhata,Shingo Kawasaki,Hitoshi Kuwabara,Takafumi Shimada,Ayako Todokoro,Takashi Igarashi,Kei-ichiro Watanabe,Hidenori Yamasue,Nobumasa Kato,Kiyoto Kasai,Yukiko Kano
発行年月	2015/11
概要	Although methylphenidate hydrochloride (MPH) is a first-line treatment for children with attention-deficit hyperactivity disorder (ADHD), the non-response rate is 30%. Our aim was to develop a supplementary neuroimaging biomarker for predicting the clinical effect of continuous MPH administration by using near-infrared spectroscopy (NIRS). After baseline assessment, we performed a double-blind, placebo-controlled, crossover trial with a single dose of MPH, followed by a prospective 4-to-8-week open trial with continuous MPH administration, and an ancillary 1-year follow-up. Twenty-two drug-naIve and eight previously treated childrenwith ADHD (NAIVE and NON-NAIVE) were compared with 20 healthy controls (HCs) who underwent multiple NIRS measurements without intervention. We tested whether NIRS signals at the baseline assessment or Delta NIRS (single dose of MPH minus baseline assessment) predict the Clinical Global Impressions-Severity (CGI-S) score after 4-to-8-week or 1-year MPH administration. The secondary outcomes were the effect of MPH on NIRS signals after single-dose, 4-to-8-week, and 1-year administration. Delta NIRS significantly predicted CGI-S after 4-to-8-week MPH admin
DOI	10.1038/npp.2015.128
PMID	25936640