クワバラ　ヒトシ   KUWABARA Hitoshi   桑原　斉    所属   埼玉医科大学  医学部 神経精神科・心療内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Clinical and neural effects of six-week administration of oxytocin on core symptoms of autism
掲載誌名	正式名：BRAIN ISSNコード：00068950
出版社	OXFORD UNIV PRESS
巻・号・頁	138(Pt 11),3400-3412頁
著者・共著者	Takamitsu Watanabe,Miho Kuroda,Hitoshi Kuwabara,Yuta Aoki,Norichika Iwashiro,Natsubori Tatsunobu,Hidemasa Takao,Yasumasa Nippashi,Yuki Kawakubo,Akira Kunimatsu,Kiyoto Kasai,Hidenori Yamasue
発行年月	2015/11
概要	Autism spectrum disorder is a prevalent neurodevelopmental disorder with no established pharmacological treatment for its core symptoms. Although previous literature has shown that single-dose administration of oxytocin temporally mitigates autistic social behaviours in experimental settings, it remains in dispute whether such potentially beneficial responses in laboratories can result in clinically positive effects in daily life situations, which are measurable only in long-term observations of individuals with the developmental disorder undergoing continual oxytocin administration. Here, to address this issue, we performed an exploratory, randomized, double-blind, placebo-controlled, crossover trial including 20 high-functional adult males with autism spectrum disorder. Data obtained from 18 participants who completed the trial showed that 6-week intranasal administration of oxytocin significantly reduced autism core symptoms specific to social reciprocity, which was clinically evaluated by Autism Diagnostic Observation Scale (P = 0.034, P-FDR< 0.05, Cohen's d = 0.78). Critically, the improvement of this clinical score was accompanied by oxytocin-induced enhancement of task-i
DOI	10.1093/brain/awv249
PMID	26336909