クワバラ　ヒトシ   KUWABARA Hitoshi   桑原　斉    所属   埼玉医科大学  医学部 神経精神科・心療内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Oxytocin receptor gene variations predict neural and behavioral response to oxytocin in autism
掲載誌名	正式名：SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE ISSNコード：17495016
出版社	OXFORD UNIV PRESS
巻・号・頁	12(3),496-506頁
著者・共著者	Takamitsu Watanabe,Takeshi Otowa,Osamu Abe,Hitoshi Kuwabara,Yuta Aoki,Tatsunobu Natsubori,Hidemasa Takao,Chihiro Kakiuchi,Kenji Kondo,Masashi Ikeda,Nakao Iwata,Kiyoto Kasai,Tsukasa Sasaki,Hidenori Yamasue
発行年月	2017/03
概要	Oxytocin appears beneficial for autism spectrum disorder (ASD), and more than 20 single-nucleotide polymorphisms (SNPs) in oxytocin receptor (OXTR) are relevant to ASD. However, neither biological functions of OXTR SNPs in ASD nor critical OXTR SNPs that determine oxytocin's effects on ASD remains known. Here, using a machine-learning algorithm that was designed to evaluate collective effects of multiple SNPs and automatically identify most informative SNPs, we examined relationships between 27 representative OXTR SNPs and six types of behavioral/neural response to oxytocin in ASD individuals. The oxytocin effects were extracted from our previous placebo-controlled within-participant clinical trial administering single-dose intranasal oxytocin to 38 high-functioning adult Japanese ASD males. Consequently, we identified six different SNP sets that could accurately predict the six different oxytocin efficacies, and confirmed the robustness of these SNP selections against variations of the datasets and analysis parameters. Moreover, major alleles of several prominent OXTR SNPs-including rs53576 and rs2254298-were found to have dissociable effects on the oxytocin efficacies. These find
DOI	10.1093/scan/nsw150
PMID	27798253