クワバラ　ヒトシ   KUWABARA Hitoshi   桑原　斉    所属   埼玉医科大学  医学部 神経精神科・心療内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Computer-analyzed facial expression as a surrogate marker for autism spectrum social core symptoms.
掲載誌名	正式名：PloS one
巻・号・頁	13(1),e0190442頁
著者・共著者	Keiho Owada,Masaki Kojima,Walid Yassin,Miho Kuroda,Yuki Kawakubo,Hitoshi Kuwabara,Yukiko Kano,Hidenori Yamasue
発行年月	2018
概要	To develop novel interventions for autism spectrum disorder (ASD) core symptoms, valid, reliable, and sensitive longitudinal outcome measures are required for detecting symptom change over time. Here, we tested whether a computerized analysis of quantitative facial expression measures could act as a marker for core ASD social symptoms. Facial expression intensity values during a semi-structured socially interactive situation extracted from the Autism Diagnostic Observation Schedule (ADOS) were quantified by dedicated software in 18 high-functioning adult males with ASD. Controls were 17 age-, gender-, parental socioeconomic background-, and intellectual level-matched typically developing (TD) individuals. Statistical analyses determined whether values representing the strength and variability of each facial expression element differed significantly between the ASD and TD groups and whether they correlated with ADOS reciprocal social interaction scores. Compared with the TD controls, facial expressions in the ASD group appeared more"Neutral"(d = 1.02, P = 0.005, PFDR<0.05) with less variation in Neutral expression (d = 1.08, P = 0.003, PFDR<0.05). Their expressions were also l
DOI	10.1371/journal.pone.0190442
PMID	29293598