クワバラ　ヒトシ   KUWABARA Hitoshi   桑原　斉    所属   埼玉医科大学  医学部 神経精神科・心療内科    職種   教授
論文種別	学術雑誌(原著)
言語種別
査読の有無	査読あり
表題	Neuroanatomical Correlates of Advanced Paternal and Maternal Age at Birth in Autism Spectrum Disorder
掲載誌名	正式名：Cerebral Cortex ISSNコード：10473211
巻・号・頁	29(6),2524-2532頁
著者・共著者	Masaki Kojima,Walid Yassin,Keiho Owada,Yuta Aoki,Hitoshi Kuwabara,Tatsunobu Natsubori,Norichika Iwashiro,Wataru Gonoi,Hidemasa Takao,Kiyoto Kasai,Osamu Abe,Yukiko Kano,Hidenori Yamasue
発行年月	2019/06
概要	© The Author(s) 2018. Published by Oxford University Press. All rights reserved. Although advanced paternal and maternal age at birth (PA/MA) increases the risk of autism spectrum disorder (ASD), the underlying neurobiological mechanisms are not fully understood. To explore the neuroanatomical correlates of advanced PA/MA, the current study conducted brain morphometric analyses in 39 high-functioning adult males with ASD and 39 age-, intellectual level-, and parental socioeconomic background-matched, typically developed (TD) males. Whole-brain analysis revealed that the regional gray matter volume (GMV) in bilateral posterior cingulate cortex (PCC) and precuneus (PCU) were significantly smaller in the individuals with ASD than in TD subjects (false discovery rate-corrected P = 0.014). Additional analyses of the constituents of GMV reduction in these brain regions revealed that the cortical thickness of the right ventral PCC was significantly thinner (P = 0.014) and the surface area of bilateral PCU was significantly smaller (left: P = 0.001; right: P = 0.049) in the adults with ASD, compared with TD subjects. Although the analyses were exploratory, the thinner cortical thickness o
DOI	10.1093/cercor/bhy122
PMID	29800092