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クワバラ ヒトシ
KUWABARA Hitoshi
桑原 斉 所属 埼玉医科大学 医学部 神経精神科・心療内科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Genetic influences on prefrontal activation during a verbal fluency task in children: A twin study using near-infrared spectroscopy |
| 掲載誌名 | 正式名：Brain and Behavior ISSNコード：21623279 |
| 出版社 | John Wiley and Sons Ltd |
| 巻・号・頁 | 8(6),e00980頁 |
| 著者・共著者 | Eisuke Sakakibara,Ryu Takizawa,Yuki Kawakubo,Hitoshi Kuwabara,Toshiaki Kono,Kasumi Hamada,Shiho Okuhata,Satoshi Eguchi,Ayaka Ishii-Takahashi,Kiyoto Kasai |
| 発行年月 | 2018/06 |
| 概要 | Objective: The genetic and environmental influences on prefrontal function in childhood are underinvestigated due to the difficulty of measuring prefrontal function in young subjects, for which near-infrared spectroscopy (NIRS) is a suitable functional neuroimaging technique that facilitates the easy and noninvasive measurement of blood oxygenation in the superficial cerebral cortices. Method: Using a two-channel NIRS arrangement, we measured changes in bilateralprefrontal blood oxygenation during a category version of the verbal fluency task (VFT) in 27 monozygotic twin pairs and 12 same-sex dizygotic twin pairs ages 5–17 years. We also assessed the participant's full-scale intelligence quotient (FIQ) and retrieved parental socioeconomic status (SES). Classical structured equation modeling was used to estimate the heritability. Results: The heritability of VFT-related brain activation was estimated to be 44% and 37% in the right and left prefrontal regions, respectively. We also identified a significant genetic contribution (74%) to FIQ, but did not to VFT task performance. Parental SES was not correlated with FIQ, task performance, or task-related prefrontal activation. Concl |
| DOI | 10.1002/brb3.980 |
| PMID | 30106245 |