クワバラ　ヒトシ   KUWABARA Hitoshi   桑原　斉    所属   埼玉医科大学  医学部 神経精神科・心療内科    職種   教授
論文種別	学術雑誌(原著)
言語種別
査読の有無	査読あり
表題	Neurochemical evidence for differential effects of acute and repeated oxytocin administration
掲載誌名	正式名：Molecular Psychiatry ISSNコード：13594184
著者・共著者	Seico Benner,Yuta Aoki,Takamitsu Watanabe,Nozomi Endo,Osamu Abe,Miho Kuroda,Hitoshi Kuwabara,Yuki Kawakubo,Hidemasa Takao,Akira Kunimatsu,Kiyoto Kasai,Haruhiko Bito,Masaki Kakeyama,Hidenori Yamasue
発行年月	2018
概要	© 2018, Springer Nature Limited. A discrepancy in oxytocin’s behavioral effects between acute and repeated administrations indicates distinct underlying neurobiological mechanisms. The current study employed a combination of human clinical trial and animal study to compare neurochemical changes induced by acute and repeated oxytocin administrations. Human study analyzed medial prefrontal metabolite levels by using 1H-magnetic resonance spectroscopy, a secondary outcome in our randomized, double-blind, placebo-controlled crossover trial of 6 weeks intranasal administrations of oxytocin (48 IU/day) and placebo within-subject design in 17 psychotropic-free high-functioning men with autism spectrum disorder. Medial prefrontal transcript expression levels were analyzed in adult male C57BL/6J mice after intraperitoneal injection of oxytocin or saline either once (200 ng/100 μL/mouse, n = 12) or for 14 consecutive days (200 ng/100 μL/mouse/day, n = 16). As the results, repeated administration of oxytocin significantly decreased the medial prefrontal N-acetylaspartate (NAA; p = 0.043) and glutamate–glutamine levels (Glx; p = 0.001), unlike the acute oxytocin. The decreases were inve
DOI	10.1038/s41380-018-0249-4
PMID	30262887