イマイ　カズオ   IMAI Kazuo   今井　一男    所属   埼玉医科大学  医学部 臨床検査医学（中央検査部）    職種   専任講師
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Antibody response patterns in COVID-19 patients with different levels of disease severity in Japan.
掲載誌名	正式名：Journal of medical virology
巻・号・頁	93(5),3211-3218頁
著者・共著者	Kazuo Imai,Yutaro Kitagawa,Sakiko Tabata,Katsumi Kubota,Mayu Nagura-Ikeda,Masaru Matsuoka,Kazuyasu Miyoshi,Jun Sakai,Noriomi Ishibashi,Norihito Tarumoto,Shinichi Takeuchi,Toshimitsu Ito,Shigefumi Maesaki,Kaku Tamura,Takuya Maeda
発行年月	2021/02
概要	We analyzed antibody response patterns according to the level of disease severity in patients with novel coronavirus disease 2019 (COVID-19) in Japan. We analyzed 611 serum specimens from 231 patients with COVID-19 (mild, 170; severe, 31; critical, 30). Immunoglobulin M (IgM) and IgG antibodies against nucleocapsid protein (N) and spike 1 protein (S1) were detected by enzyme-linked immunosorbent assays. The peaks of fitting curves for the optical density (OD) values of IgM and IgG antibodies against N appeared simultaneously, while those against S1 were delayed compared with N. The OD values of IgM against N and IgG against both N and S1 were significantly higher in the severe and critical cases than in the mild cases at 11 days after symptom onset. The seroconversion rates of IgG were higher than those of IgM against both N and S1 during the clinical course based on the optimal cut-off values defined in this study. The seroconversion rates of IgG and IgM against N and S1 were higher in the severe and critical cases than in the mild cases. Our findings show that a stronger antibody response occurred in COVID-19 patients with greater disease severity and there were low seroconversio
DOI	10.1002/jmv.26899
PMID	33620098