イノウエ　ツトム   INOUE Tsutomu   井上　勉    所属   埼玉医科大学  医学部 大学病院　腎臓内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Reappraisal of profibrotic phenotype and cell-cycle state of renal tubular epithelium after ischemia-reperfusion injury.
掲載誌名	正式名：PloS one 略　 称：PLoS One ISSNコード：19326203/19326203
掲載区分	国外
巻・号・頁	21(4),e0347835頁
著者・共著者	Fukaya Daichi, Kosakai Wakako, Sato Tetsuya, Inoue Tsutomu, Amano Hiroaki, Kusano Takeru, Okada Hirokazu
発行年月	2026/04/24
概要	Pro-fibrotic phenotypes in tubular epithelial cells were not exclusively acquired by G2/M-arrested cells, as reported in previous studies, but can also be acquired by cells in the quiescent G0/G1 phase during normal cell cycling. To develop novel therapeutics for chronic kidney disease, regulating pro-fibrotic gene expression in injured tubular epithelial cells, independent of specific cell cycle phases, appears to be crucial.
DOI	10.1371/journal.pone.0347835
PMID	42030280