ナガイ　ヨシアキ   NAGAI Yoshiaki   長井　良昭    所属   埼玉医科大学  医学部 呼吸器内科    職種   教授
論文種別	学術雑誌(症例報告)
言語種別	英語
査読の有無	査読あり
表題	First Reported Case of Pure Red Cell Aplasia Related to Sotorasib.
掲載誌名	正式名：Internal medicine (Tokyo, Japan) ISSNコード：13497235/09182918/09182918
掲載区分	国内
巻・号・頁	64,1089-1092頁
著者・共著者	Itogawa K, Saito T, Nakata Y, Amari H, Tahara H, Yoshino N, Maeda Y, Nomura M, Shiihara J, Nagai Y, Ohta H, Yamaguchi Y
発行年月	2025/04
概要	We herein report a 64-year-old man with KRAS(G12C)-mutated advanced lung adenocarcinoma previously treated with immune checkpoint inhibitors (ICIs). One month after starting second-line sotorasib treatment, the patient experienced a progressive decline in serum hemoglobin levels. Anemia was accompanied by markedly elevated serum erythropoietin levels and decreased reticulocyte levels. Bone marrow aspiration revealed pure red cell aplasia. No secondary causes other than medication use were identified. Suspected causative drugs were sotorasib and ICIs. Discontinuation of sotorasib for one week improved his anemia; therefore, the causative drug was identified as sotorasib.