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ヨツモト ジュンコ
YOTSUMOTO Junko
四元 淳子 所属 埼玉医科大学 医学部 ゲノム医療科 職種 専任講師 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Classification of factors involved in nonreportable results of noninvasive prenatal testing (NIPT) and prediction of success rate of second NIPT. |
| 掲載誌名 | 正式名：Prenatal diagnosis 略 称：Prenat Diagn ISSNコード：10970223/01973851 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 39(2),100-106頁 |
| 著者・共著者 | Suzumori Nobuhiro, Sekizawa Akihiko, Takeda Eri, Samura Osamu, Sasaki Aiko, Akaishi Rina, Wada Seiji, Hamanoue Haruka, Hirahara Fumiki, Kuriki Hiroko, Sawai Hideaki, Nakamura Hiroaki, Yamada Takahiro, Miura Kiyonori, Masuzaki Hideaki, Yamashita Takahiro, Kamei Yoshimasa, Namba Akira, Murotsuki Jun, Tanemoto Tomohiro, Fukushima Akimune, Haino Kazufumi, Tairaku Shinya, Matsubara Keiichi, Maeda Kazutoshi, Kaji Takashi, Ogawa Masanobu, Osada Hisao, Nishizawa Haruki, Okamoto Yoko, Kanagawa Takeshi, Kakigano Aiko, Endo Masayuki, Kitagawa Michihiro, Ogawa Masaki, Izumi Shunichiro, Katagiri Yukiko, Takeshita Naoki, Kasai Yasuyo, Naruse Katsuhiko, Neki Reiko, Masuyama Hisashi, Hyodo Maki, Kawano Yukie, Ohba Takashi, Ichizuka Kiyotake, Nagamatsu Takeshi, Watanabe Atsushi, Nishikawa Naomi, Hamajima Naoki, Shirato Nahoko, Yotsumoto Junko, Nishiyama Miyuki, Koide Keiko, Hirose Tatsuko, Sago Haruhiko |
| 発行年月 | 2019/01 |
| 概要 | OBJECTIVE: To evaluate reasons for nonreportable cfDNA results in NIPT, we retrospectively studied associated maternal characteristics and details.
METHODS: A multicenter retrospective cohort study analyzed data from pregnant women with failed cfDNA tests using massively parallel sequencing (MPS) between April 2013 and March 2017. RESULTS: Of 34,626 women, 110 (0.32%) had initial nonreportable results. Key reasons were low FF (<4%) in 22 cases (20.0%) and altered genomic profiles, including maternal malignancy, in 18 cases (16.4%). Approximately half had borderline z scores. For altered genomic profiles, retesting success rates were low (25.0%–33.3%). Thirteen women (11.8%) received hypodermic heparin. CONCLUSIONS: Classifying nonreportable cfDNA results is crucial for providing precise information and reducing maternal anxiety. |
| DOI | 10.1002/pd.5408 |
| PMID | 30586157 |