ヨツモト　ジュンコ   YOTSUMOTO Junko   四元　淳子    所属   埼玉医科大学  医学部 ゲノム医療科    職種   専任講師
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Performance and outcomes of noninvasive prenatal testing for twin pregnancies in Japan.
掲載誌名	正式名：The journal of obstetrics and gynaecology research 略　 称：J Obstet Gynaecol Res ISSNコード：14470756/13418076
掲載区分	国外
巻・号・頁	44(10),1909-1914頁
著者・共著者	Takeda Eri, Suzumori Nobuhiro, Kumagai Kyoko, Inuzuka Saki, Oseto Kumiko, Ohigashi Yuka, Yotsumoto Junko, Miyake Hidehiko, Sugiura-Ogasawara Mayumi
発行年月	2018/10
概要	AIM: This study aimed to describe the characteristics of women with twin pregnancies undergoing NIPT, along with postpartum and neonatal outcomes in Japan. METHODS: We reviewed twin pregnancy cases that underwent NIPT using massively parallel sequencing at Nagoya City University Hospital between April 2013 and June 2016. Questionnaires were completed pre-NIPT and postpartum. RESULTS: Of 4,009 women undergoing NIPT, 75 (1.9%) had twin pregnancies. Fifteen (20.0%) experienced vanishing twin/fetal death at <22 weeks, while 60 (80.0%) had normal twin pregnancies at genetic counseling. NIPT use correlated with increased assisted reproductive technology use. The test performed well, showing a 1.7% false-positive rate and zero false negatives. CONCLUSION: NIPT demonstrated high performance in twin pregnancies. Its efficacy should be explained during genetic counseling for twins, though larger studies are required to confirm reliability and validity.
DOI	10.1111/jog.13744
PMID	30015363