ヨツモト　ジュンコ   YOTSUMOTO Junko   四元　淳子    所属   埼玉医科大学  医学部 ゲノム医療科    職種   専任講師
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Fetal cell-free DNA fraction in maternal plasma for the prediction of hypertensive disorders of pregnancy.
掲載誌名	正式名：European journal of obstetrics, gynecology, and reproductive biology 略　 称：Eur J Obstet Gynecol Reprod Biol ISSNコード：18727654/03012115
掲載区分	国外
巻・号・頁	224,165-169頁
著者・共著者	Suzumori Nobuhiro, Sekizawa Akihiko, Ebara Takeshi, Samura Osamu, Sasaki Aiko, Akaishi Rina, Wada Seiji, Hamanoue Haruka, Hirahara Fumiki, Izumi Haruna, Sawai Hideaki, Nakamura Hiroaki, Yamada Takahiro, Miura Kiyonori, Masuzaki Hideaki, Yamashita Takahiro, Okai Takashi, Kamei Yoshimasa, Namba Akira, Murotsuki Jun, Tanemoto Tomohiro, Fukushima Akimune, Haino Kazufumi, Tairaku Shinya, Matsubara Keiichi, Maeda Kazutoshi, Kaji Takashi, Ogawa Masanobu, Osada Hisao, Nishizawa Haruki, Okamoto Yoko, Kanagawa Takeshi, Kakigano Aiko, Kitagawa Michihiro, Ogawa Masaki, Izumi Shunichiro, Katagiri Yukiko, Takeshita Naoki, Kasai Yasuyo, Naruse Katsuhiko, Neki Reiko, Masuyama Hisashi, Hyodo Maki, Kawano Yukie, Ohba Takashi, Ichizuka Kiyotake, Nagamatsu Takeshi, Watanabe Atsushi, Shirato Nahoko, Yotsumoto Junko, Nishiyama Miyuki, Hirose Tatsuko, Sago Haruhiko
発行年月	2018/05
概要	OBJECTIVE: This study aimed to compare fetal fractions (FFs) during NIPT in singleton pregnancies by gestational age and maternal characteristics, evaluating its utility for predicting complications like gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP). STUDY DESIGN: This multicenter prospective cohort study collected data from women with negative NIPT results. Relationships between FFs and gestational age, maternal weight/height, and incidences of miscarriage, preterm delivery, GDM, HDP, and placental abruption were assessed. RESULTS: Among 5,582 registered women with negative NIPT results, demographic analysis showed that those with HDP tended to have low FFs during early gestation. The area under the curve (AUC) in a receiver operating characteristic (ROC) analysis was 0.608 for women with HDP. CONCLUSION: A low FF on NIPT might correlate with future HDP. However, predicting HDP during early pregnancy based on a low FF remains difficult.
DOI	10.1016/j.ejogrb.2018.03.048
PMID	29605711