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ヨツモト ジュンコ
YOTSUMOTO Junko
四元 淳子 所属 埼玉医科大学 医学部 ゲノム医療科 職種 専任講師 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Maternal smoking and placental expression of a panel of genes related to angiogenesis and oxidative stress in early pregnancy. |
| 掲載誌名 | 正式名：Fetal diagnosis and therapy 略 称：Fetal Diagn Ther ISSNコード：14219964/10153837 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 35(4),289-95頁 |
| 著者・共著者 | Shinjo Azusa, Ventura Walter, Koide Keiko, Hori Kyouko, Yotsumoto Junko, Matsuoka Ryu, Ichizuka Kiyotake, Sekizawa Akihiko |
| 発行年月 | 2014 |
| 概要 | OBJECTIVE: This study investigated the impact of maternal smoking on early placental expression of angiogenesis and oxidative stress genes, which may relate to the reduced preeclampsia risk in smokers.
METHODS: Villous tissue samples were collected at 6–7 and 10–11 weeks of gestation from 31 women undergoing surgical termination. Maternal smoking status was verified by serum cotinine. Placental expression of VEGFA, Flt-1, sEng, PlGF, HMOX-1, and SOD was measured using real-time PCR. RESULTS: VEGFA expression was significantly higher in smoking women than in nonsmoking women at 10–11 weeks of gestation. No significant difference was observed at 6–7 weeks, and expression of the other genes did not vary by smoking status. CONCLUSION: Elevated placental VEGFA expression at 10–11 weeks in smoking women may contribute to their decreased risk of developing preeclampsia. |
| DOI | 10.1159/000357704 |
| PMID | 24642658 |