ヨツモト　ジュンコ   YOTSUMOTO Junko   四元　淳子    所属   埼玉医科大学  医学部 ゲノム医療科    職種   専任講師
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Placental expression of microRNA-17 and -19b is down-regulated in early pregnancy loss.
掲載誌名	正式名：European journal of obstetrics, gynecology, and reproductive biology 略　 称：Eur J Obstet Gynecol Reprod Biol ISSNコード：18727654/03012115
掲載区分	国外
巻・号・頁	169(1),28-32頁
著者・共著者	Ventura Walter, Koide Keiko, Hori Kyoko, Yotsumoto Junko, Sekizawa Akihiko, Saito Hiroshi, Okai Takashi
発行年月	2013/07
概要	OBJECTIVE: This study evaluated whether microRNA-17 and -19b are expressed in early pregnancy villous samples and if their expression, along with targets (PTEN, CREB-1, TGF$\beta$-1, TGF$\beta$-RII), is altered in early pregnancy loss.STUDY DESIGN: Expression levels in villous samples from early pregnancy loss ($n=11$) and gestational age-matched normal cases ($n=20$) were determined by RT-PCR.RESULTS: Both microRNA-17 and -19b were expressed in normal pregnancies but significantly down-regulated in early pregnancy loss (ratios: 0.35 and 0.34). Their target, PTEN mRNA, was significantly up-regulated (ratio: 2.6). TGF-$\beta$1, CREB-1, and TGF$\beta$-RII showed no significant differences.CONCLUSION: microRNA-17 and -19b are expressed in early pregnancy and down-regulated in early pregnancy loss. These microRNA-17-92 cluster members may be involved in placental invasion, and their dysregulation could relate to defective placentation conditions.
DOI	10.1016/j.ejogrb.2013.01.025
PMID	23433743