ヨツモト　ジュンコ   YOTSUMOTO Junko   四元　淳子    所属   埼玉医科大学  医学部 ゲノム医療科    職種   専任講師
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Physiological changes in the pattern of placental gene expression early in the first trimester.
掲載誌名	正式名：Reproductive sciences (Thousand Oaks, Calif.) 略　 称：Reprod Sci ISSNコード：19337205/19337191
掲載区分	国外
巻・号・頁	20(6),710-4頁
著者・共著者	Miyagami Satoshi, Koide Keiko, Sekizawa Akihiko, Ventura Walter, Yotsumoto Junko, Oishi Shingo, Okai Takashi
発行年月	2013/06
概要	OBJECTIVE: This study assessed physiological changes in the placental expression of genes related to angiogenesis and oxidative stress during the early first trimester.METHODS & RESULTS: Gene expression was quantified via RT-PCR in villous trophoblast samples from women at 6–11 weeks of gestation undergoing elective abortion. Messenger RNA (mRNA) levels of placental growth factor (PlGF; $r=.37, P=.001$), heme oxygenase 1 (HO-1; $r=.24, P=.04$), and superoxide dismutase (SOD; $r=.52, P<.001$) increased significantly with gestational age. Conversely, fms-like tyrosine kinase 1 (FLT-1) mRNA expression decreased significantly ($r=-.30, P=.009$).CONCLUSION: During the early first trimester, placental expression of PlGF, HO-1, and SOD increases with gestational age, while FLT-1 decreases. Alterations in this gene expression pattern may play an important role in placenta-related disorders like preeclampsia.
DOI	10.1177/1933719112466309
PMID	23232967