クワバラ　ヒトシ   KUWABARA Hitoshi   桑原　斉    所属   埼玉医科大学  医学部 神経精神科・心療内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	A key gene modulating oxytocin efficacy in autism: genome-wide discovery and verification in randomized controlled trials datasets.
掲載誌名	正式名：Molecular psychiatry 略　 称：Mol Psychiatry ISSNコード：14765578/13594184
掲載区分	国外
著者・共著者	Kuwabara Hitoshi, Kojima Masaki, Benner Seico, Otowa Takeshi, Watanabe Takamitsu, Kuroda Miho, Owada Keiho, Yassin Walid, Hamada Junko, Kano Yukiko, Uno Yota, Kushima Itaru, Mori Daisuke, Arioka Yuko, Munesue Toshio, Kasai Kiyoto, Higashida Haruhiro, Abe Osamu, Takao Hidemasa, Wakuda Tomoyasu, Kameno Yosuke, Inoue Jun, Harada Taeko, Yamauchi Aya, Ogawa Nanayo, Honda Nami, Kikuchi Saya, Seto Moe, Tomita Hiroaki, Miyoshi Noriko, Matsumoto Megumi, Kawaguchi Yuko, Kanai Koji, Ikeda Manabu, Nakamura Itta, Isomura Shuichi, Hirano Yoji, Onitsuka Toshiaki, Takahashi Nagahide, Nakashima Mitsuko, Saitsu Hirotomo, Kondo Kenji, Ikeda Masashi, Iwata Nakao, Shimada Mihoko, Sasaki Tsukasa, Takei Nori, Ozaki Norio, Kosaka Hirotaka, Okada Takashi, Yamasue Hidenori
発行年月	2026/03
概要	In this study, we conducted a genome-wide association study (GWAS) using data from a randomized controlled trial (RCT) that examined the effects of a single dose oxytocin on behavioral and neural correlates of ASD. We further tested the association between the SNP identified in the GWAS and clinical efficacy in an independent, larger dataset comprising participants from three additional RCTs. The GWAS identified a significant association between oxytocin-induced improvements in medial prefrontal cortex activity during a social judgment task and the single nucleotide polymorphism (SNP) rs1871303 in the ryanodine receptor 2 (RYR2) gene (β = 2.37, t = 7.82, df = 72, P = 3.47 × 10⁻⁹). The validation analysis supported the association between this RYR2 SNP and individual variability in ADOS reciprocity improvement (β = 0.194, t = 2.30, df = 135, P = 0.023), with no significant association observed for placebo response (P > 0.1).
DOI	10.1038/s41380-026-03562-y
PMID	41904269