カワムラ　ヒデマサ   KAWAMURA Hidemasa   河村　英将    所属   埼玉医科大学  医学部 総合医療センター　放射線科(画像診断・核医学科、放射線腫瘍科)    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Technical approach to individualized respiratory-gated carbon-ion therapy for mobile organs
掲載誌名	正式名：Radiological Physics and Technology ISSNコード：1865-0333
巻・号・頁	6(2),356-366頁
著者・共著者	Mutsumi Tashiro,Takayoshi Ishii,Jun-Ichi Koya,Ryosuke Okada,Yuji Kurosawa,Keisuke Arai,Satoshi Abe,Yoshiaki Ohashi,Hirofumi Shimada,Ken Yusa,Tatsuaki Kanai,Satoru Yamada,Hidemasa Kawamura,Takeshi Ebara,Tatsuya Ohno,Takashi Nakano
発行年月	2013/07
概要	We propose a strategy of individualized image acquisitions and treatment planning for respiratory-gated carbon-ion therapy. We implemented it in clinical treatments for diseases of mobile organs such as lung cancers at the Gunma University Heavy Ion Medical Center in June 2010. Gated computed tomography (CT) scans were used for treatment planning, and four-dimensional (4D) CT scans were used to evaluate motion errors within the gating window to help define the internal margins (IMs) and planning target volume for each patient. The smearing technique or internal gross tumor volume (IGTV = GTV + IM), where the stopping power ratio was replaced with the tumor value, was used for range compensation of moving targets. Dose distributions were obtained using the gated CT images for the treatment plans. The influence of respiratory motion on the dose distribution was verified with the planned beam settings using 4D CT images at some phases within the gating window before the adoption of the plan. A total of 14 lung cancer patients were treated in the first year. The planned margins with the proposed method were verified with clinical X-ray set-up images by deriving setup and internal motion errors. The planned margins were considered to be reasonable compared with the errors, except for large errors observed in some cases. © 2013 The Author(s).
DOI	10.1007/s12194-013-0208-3
PMID	23568337