カワムラ　ヒデマサ   KAWAMURA Hidemasa   河村　英将    所属   埼玉医科大学  医学部 総合医療センター　放射線科(画像診断・核医学科、放射線腫瘍科)    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Prospective observational study of carbon-ion radiotherapy for non-squamous cell carcinoma of the head and neck.
掲載誌名	正式名：Cancer science ISSNコード：1347-9032
掲載区分	国外
巻・号・頁	108(10),2039-2044頁
著者・共著者	Katsuyuki Shirai,Jun-Ichi Saitoh,Atsushi Musha,Takanori Abe,Daijiro Kobayashi,Takeo Takahashi,Tomoaki Tamaki,Hidemasa Kawamura,Yukihiro Takayasu,Masato Shino,Minoru Toyoda,Katsumasa Takahashi,Junko Hirato,Satoshi Yokoo,Kazuaki Chikamatsu,Tatsuya Ohno,Tatsuya Nakano
発行年月	2017/10
概要	To evaluate the efficacy and safety of carbon-ion radiotherapy for non-squamous cell carcinoma of the head and neck, 35 patients were enrolled in this prospective study. The primary end-point was the 3-year local control rate, and the secondary end-points included the 3-year overall survival rate and adverse events. Acute and late adverse events were evaluated according to the Common Terminology Criteria for Adverse Events, version 4.0. The median follow-up time for all patients was 39 months. Thirty-two and three patients received 64.0 Gy (relative biological effectiveness) and 57.6 Gy (relative biological effectiveness) in 16 fractions, respectively. Adenoid cystic carcinoma was dominant (60%). Four patients had local recurrence and five patients died. The 3-year local control and overall survival rates were 93% and 88%, respectively. Acute grade 2-3 radiation mucositis (65%) and dermatitis (31%) was common, which improved immediately with conservative therapy. Late mucositis of grade 2, grade 3, and grade 4 were observed in 11, one, and no patients, respectively. There were no adverse events of grade 5. Carbon-ion radiotherapy achieved excellent local control and overall survival rates for non-squamous cell carcinoma. However, the late mucosal adverse events were not rare, and meticulous treatment planning is required. Trial registration no. UMIN000007886.
DOI	10.1111/cas.13325
PMID	28730646