カワムラ　ヒデマサ   KAWAMURA Hidemasa   河村　英将    所属   埼玉医科大学  医学部 総合医療センター　放射線科(画像診断・核医学科、放射線腫瘍科)    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Mild Hypofractionated Radiation Therapy for Merkel Cell Carcinoma
掲載誌名	正式名：Cureus ISSNコード：2168-8184
掲載区分	国外
出版社	Cureus, Inc.
巻・号・頁	12(1),e6786頁
著者・共著者	Toshiaki Matsui,Naoko Okano,Hidemasa Kawamura,Takahiro Oike,Tatsuya Ohno
発行年月	2020/01/27
概要	Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine neoplasm. Although surgical resection is the first-line treatment for primary MCCs, the characteristics of this disease (i.e., high prevalence in the elderly and in the head and neck region) generate a considerable number of inoperable cases. Radiation therapy shows potential as a definitive treatment alternative to surgery. In definitive radiation therapy for non-resected MCC, 60-66 Gy administered in 2 Gy per fraction and five fractions per week is recommended. However, such frequent visits to the hospital can be a great burden to elderly patients and family members. In this report, we present the case of an 89-year-old patient with MCC (cT2N0M0, stage IIA) of the left cheek. The patient was treated with radiation therapy using a mild hypofractionated schedule (57 Gy provided in 3 Gy per fraction and three fractions per week) targeting the gross tumor. The treatment led to complete tumor remission with well-tolerated acute toxicities at three months post-irradiation. This case indicates that a mild hypofractionated irradiation schedule may achieve tumor control in MCC patients who are inoperable and who cannot make frequent hospital visits.
DOI	10.7759/cureus.6786
PMID	32140346
PermalinkURL	https://www.cureus.com/articles/26613-mild-hypofractionated-radiation-therapy-for-merkel-cell-carcinoma