カワムラ　ヒデマサ   KAWAMURA Hidemasa   河村　英将    所属   埼玉医科大学  医学部 総合医療センター　放射線科(画像診断・核医学科、放射線腫瘍科)    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Dose assessment for patients with stage I non-small cell lung cancer receiving passive scattering carbon-ion radiotherapy using daily computed tomographic images: A prospective study
掲載誌名	正式名：Radiotherapy and Oncology ISSNコード：0167-8140
掲載区分	国外
出版社	Elsevier BV
巻・号・頁	144,224-230頁
著者・共著者	Yang Li,Yoshiki Kubota,Nobuteru Kubo,Tatsuji Mizukami,Makoto Sakai,Hidemasa Kawamura,Daisuke Irie,Naoko Okano,Kazuhisa Tsuda,Akihiko Matsumura,Jun-ichi Saitoh,Takashi Nakano,Tatsuya Ohno
発行年月	2020/03
概要	BACKGROUND AND PURPOSE: This study aimed to assess dose distributions for stage I non-small cell lung cancer (NSCLC) with passive scattering carbon-ion radiotherapy (C-ion RT) using daily computed tomography (CT) images. MATERIALS AND METHODS: We enrolled 10 patients with stage I NSCLC and acquired a total of 40 pre-fractional CT image series under the same settings as the planning CT images. These CT images were registered with planning CT images for dose evaluation using both bone matching (BM) and tumor matching (TM). Using deformable image registration, we generated accumulated doses. Moreover, the volumetric dose parameters were compared in terms of tumor coverage and lung exposure and statistical analyses were performed. RESULTS: Overall, 25% of 40 fractional dose distributions were unacceptable with BM, compared with 2.5% with TM (P < 0.001). Using BM, three patients' accumulated dose distributions were unacceptable; however, all were satisfactory with TM (P < 0.001). No differences were observed in water-equivalent path length (WEL). The required margins in patients with poor dose distribution were 5.9 and 4.4 mm for BM and TM, respectively. CONCLUSIONS: This study establishes that CT image-based TM is robust compared with conventional BM for both daily and accumulated dose distributions. The effects of changes in WEL seem to be limited. Hence, daily CT alignment is recommended for patients with stage I NSCLC receiving C-ion RT.
DOI	10.1016/j.radonc.2020.01.003
PMID	32044421