カワムラ　ヒデマサ   KAWAMURA Hidemasa   河村　英将    所属   埼玉医科大学  医学部 総合医療センター　放射線科(画像診断・核医学科、放射線腫瘍科)    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Evaluation of Carbon Ion Radiation-Induced Trismus in Head and Neck Tumors Using Dose-Volume Histograms
掲載誌名	正式名：Cancers ISSNコード：2072-6694
掲載区分	国外
出版社	MDPI AG
巻・号・頁	12(11),3116-3116頁
著者・共著者	Atsushi Musha,Hirofumi Shimada,Nobuteru Kubo,Hidemasa Kawamura,Naoko Okano,Yuhei Miyasaka,Hiro Sato,Katsuyuki Shirai,Jun-ichi Saitoh,Satoshi Yokoo,Kazuaki Chikamatsu,Tatsuya Ohno
発行年月	2020/10/25
概要	Carbon ion radiotherapy (C-ion RT) provides a highly localized deposition of energy that can increase radiation doses to tumors while minimizing irradiation of adjacent normal tissues. For tumors located near the temporomandibular joint, C-ion RT-induced trismus may occur. However, the relationship between the carbon ion dose and the onset of trismus is unclear. In this prospective observational study, we assessed the trismus/carbon ion dose relationship using dose−volume histograms in 35 patients who received C-ion RT in their head and neck regions between 2010 and 2014. Trismus was evaluated in patients according to the Common Terminology Criteria for Adverse Events, version 4.0. All patients were treated with 57.6 or 64.0 Gy (relative biological effectiveness (RBE)) in 16 fractions, and the median follow-up time was 57 months. Grade 2 trismus was observed in six patients. The median onset time was 12 months. At maximum radiation doses, all masticatory muscles and coronoid processes, particularly the masseter muscle, were significantly different (p = 0.003). The contouring of the masseter muscle and coronoid process requires different treatment planning. The maximum radiation doses of the coronoid process can be proposed as a guideline for treatment planning, considering the ease of contouring in C-ion RT.
DOI	10.3390/cancers12113116
PMID	33113829
PermalinkURL	https://www.mdpi.com/2072-6694/12/11/3116/pdf