カワムラ　ヒデマサ   KAWAMURA Hidemasa   河村　英将    所属   埼玉医科大学  医学部 総合医療センター　放射線科(画像診断・核医学科、放射線腫瘍科)    職種   教授
論文種別	学術雑誌(原著)
言語種別	日本語
査読の有無	査読なし
表題	Prospective observational study of patients treated with carbon-ion radiotherapy for non-squamous cell carcinoma of the head and neck in Gunma university
掲載誌名	正式名：Japanese Journal of Head and Neck Cancer ISSNコード：1881-8382
出版社	Japan Society for Head and Neck Cancer
巻・号・頁	47(1),53-58頁
著者・共著者	Atsushi Musha,Nobuteru Kubo,Naoko Okano,Takuya Kaminuma,Hidemasa Kawamura,Hiro Sato,Yukihiro Takayasu,Masato Shino,Osamu Nikkuni,Shota Ida,Katsuyuki Shirai,Jun-Ichi Saitoh,Masaru Ogawa,Satoshi Yokoo,Kazuaki Chikamatsu,Tatsuya Ohno
発行年月	2021
概要	Gunma University has been utilizing carbon-ion radiotherapy as a treatment for head and neck cancer since 2010. We evaluated the long-term efficacy and safety of carbon-ion radiotherapy for non-squamous cell carcinoma of the head and neck in 35 patients enrolled in a pective study at the Gunma University Heavy Ion Medical Center (from 2010 to 2014). The median age of the patients was 59 years (range, 31-77 years). The median follow-up time for all the patients was 65 months (range, 6.1-98.8 months). Thirty-two and three patients received 64.0 Gy (relative biological effectiveness) and 57.6 Gy (relative biological effectiveness) in 16 fractions, respectively. The T-classification was 5/8/22 in T2/3/4, respectively, and the tumors were inoperable in 20 cases (57％). The maxillary sinus and nasal cavity were the most common sites for tumors in 9 cases (26％). Adenoid cystic carcinoma was dominant, with this carcinoma being found in 21 cases (60％). The 5-year local control, progression-free survival, and overall survival rates were 74.5％, 53.2％, and 81.3％, respectively. Nine patients had local recurrence, and six patients died. Acute and late adverse events were evaluated according to the Common Terminology Criteria for Adverse Events, version 4.0. Over acute grade 3 radiation mucositis (8 cases) improved immediately with conservative therapy. Late grade 4 adverse events were observed these were two cases of visual loss and one case of brain necrosis. There were no grade 5 adverse events. Carbon-ion radiotherapy achieved excellent local control and overall survival rates for non-squamous cell carcinoma.
DOI	10.5981/jjhnc.47.53