カワムラ　ヒデマサ   KAWAMURA Hidemasa   河村　英将    所属   埼玉医科大学  医学部 総合医療センター　放射線科(画像診断・核医学科、放射線腫瘍科)    職種   教授
論文種別	学術雑誌(原著)
言語種別
査読の有無	査読なし
表題	Dosimetric Parameters Predicting Tooth Loss after Carbon Ion Radiotherapy for Head and Neck Tumors
掲載誌名	正式名：Radiation ISSNコード：2673-592X
出版社	MDPI AG
巻・号・頁	1(3),183-193頁
著者・共著者	Nobuteru Kubo,Makoto SAKAI,Hidemasa Kawamura,Takahiro Oike,Yoshiki Kubota,Mai Anakura,Akiko Adachi,Hiro Sato,Atsushi Musha,Naoko Okano,Takuya Kaminuma,Katsuyuki Shirai,Jun-ichi Saitoh,Satoshi Yokoo,Kazuaki Chikamatsu,Tatsuya Ohno
発行年月	2021/07/09
概要	Background: Tooth loss reduces quality of life; however, little is known about tooth loss caused by carbon ion radiotherapy (CIRT). Here, we aimed to elucidate the incidence of tooth loss post-CIRT for head and neck tumors and to identify risk-predictive dosimetric parameters. Methods: This study enrolled 14 patients (i.e., 171 teeth in total) with head and neck non-squamous cell carcinoma. All patients received CIRT comprised of 57.6 or 64.0 Gy (relative biological effectiveness, RBE) in 16 fractions. Dose–volume analysis of the teeth was performed using receiver operating characteristic (ROC) curve analysis with VX (i.e., the volume irradiated with X Gy (RBE)). Results: The median follow-up period was 69.1 months. The median time of tooth loss was 38.6 months. The 5 year cumulative incidence of tooth loss was 13.3%. The volume of irradiated teeth was significantly greater for the lost teeth than for the remaining teeth throughout the dose range. Using the cut-offs calculated from ROC curve analysis, V30–V60 showed high accuracy (i.e., >94%) for predicting tooth loss, with V50 being the most accurate (cut-off, 58.1%; accuracy, 0.95). Conclusions: This is the first report to examine the incidence of tooth loss post-CIRT and to identify risk-predictive dosimetric parameters.
DOI	10.3390/radiation1030017
ORCIDのPut Code	96940695
PermalinkURL	https://www.mdpi.com/2673-592X/1/3/17/pdf