|
カワムラ ヒデマサ
KAWAMURA Hidemasa
河村 英将 所属 埼玉医科大学 医学部 総合医療センター 放射線科(画像診断・核医学科、放射線腫瘍科) 職種 教授 |
|
| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | Efficacy and Safety of Carbon-Ion Radiotherapy for Stage I Non-Small Cell Lung Cancer with Coexisting Interstitial Lung Disease |
| 掲載誌名 | 正式名：Cancers ISSNコード：2072-6694 |
| 掲載区分 | 国外 |
| 出版社 | MDPI AG |
| 巻・号・頁 | 13(16),4204-4204頁 |
| 著者・共著者 | Naoko Okano,Nobuteru Kubo,Koichi Yamaguchi,Shunichi Kouno,Yuhei Miyasaka,Tatsuji Mizukami,Katsuyuki Shirai,Jun-ichi Saitoh,Takeshi Ebara,Hidemasa Kawamura,Toshitaka Maeno,Tatsuya Ohno |
| 発行年月 | 2021/08/20 |
| 概要 | Interstitial lung disease (ILD) is a risk factor both for the development and treatment failure of lung cancer. In this retrospective study, we analyzed the outcome of carbon-ion radiotherapy (CIRT) in 124 patients with clinical stage I non-small cell lung cancer (NSCLC), of whom 26 (21%) had radiological signs of pre-existing ILD. ILD was diagnosed retrospectively by a pulmonologist based on critical review of CT-scans. Ninety-eight patients were assigned to the non-ILD group and 26 patients (21.0%) to the ILD group. There were significant differences in pre-treatment KL-6 values between the two groups. The three year overall survival and cause-specific survival rates were 83.2% and 90.7%, respectively, in the non-ILD group, and 59.7% and 59.7%, respectively, in the ILD group (between-group differences, p = 0.002 and p < 0.001). Radiation pneumonitis worse than Grade 2 was observed in three patients (3.0%) in the non-ILD group and two patients (7.6%) in the ILD group (p = 0.29). There were no cases of acute exacerbation in the ILD group. CIRT for stage I NSCLC was as safe in the ILD group as in the non-ILD group. Coexisting ILD was a poor prognostic factor in CIRT for clinical stage I lung cancer. |
| DOI | 10.3390/cancers13164204 |
| PMID | 34439358 |
| PermalinkURL | https://www.mdpi.com/2072-6694/13/16/4204/pdf |