カワムラ　ヒデマサ   KAWAMURA Hidemasa   河村　英将    所属   埼玉医科大学  医学部 総合医療センター　放射線科(画像診断・核医学科、放射線腫瘍科)    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Relationship between oral mucositis and the oral bacterial count in patients with head and neck cancer undergoing carbon ion radiotherapy: A prospective study
掲載誌名	正式名：Radiotherapy and Oncology ISSNコード：0167-8140
掲載区分	国外
出版社	Elsevier BV
巻・号・頁	167,65-71頁
著者・共著者	Atsushi Musha,Chika Hirai,Yoko Kitada,Anna Tsunoda,Hirofumi Shimada,Nobuteru Kubo,Hidemasa Kawamura,Naoko Okano,Hiro Sato,Kohei Okada,Akiko Adachi,Satoshi Yokoo,Kazuaki Chikamatsu,Tatsuya Ohno
発行年月	2021/12
概要	BACKGROUND AND PURPOSE: Acute adverse events, such as oral mucositis, can affect treatment success in patients undergoing head and neck radiotherapy. In this study, we aimed to identify the relationship between oral mucositis and oral bacterial counts during carbon ion radiotherapy (C-ion RT) in patients with head and neck cancer. MATERIALS AND METHODS: This prospective study included patients with head and neck tumors treated with C-ion RT between 2017 and 2019. C-ion RT consisted of treatment at 57.6, 64.0, or 70.4 Gy (relative biological effectiveness) in 16 fractions. Bacterial counts in the saliva and the back of the tongue were measured using a rapid oral bacteria quantification system. The relationship between the oral bacterial count and oral mucositis was subsequently analyzed. RESULTS: In total, 46 patients were included in the analysis. The bacterial count in the saliva gradually increased from the commencement of C-ion RT and peaked at 16 fractions. Bacterial counts at the back of the tongue were already high at the beginning of C-ion RT; however, they decreased with continued treatment, peaked at 16 fractions, and subsequently decreased again. Patients with bacterial counts exceeding the mean before C-ion RT (high-count group) did not experience more severe mucositis than those with counts below the mean (low-count group). However, patients in the high-count group tended to experience faster-onset mucositis and slower healing than those in the low-count group. CONCLUSION: Bacterial counts may aid in the development of clinical strategies for C-ion RT-induced oral mucositis.
DOI	10.1016/j.radonc.2021.12.010
PMID	34902372